Academic Qualification

‍2009: Ph. D. degree in Pharmaceutical Chemistry, Joint Supervision Program: Faculty of Pharmacy, Buffalo, State University of New York, NY, USA & Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Work Experiences

• May 2021- Current: Professor
  Pharmaceutical Sciences Department, Fakeeh College for Medical Sciences
• Mar 2019- May 2021: Associate Professor
  Pharmaceutical Sciences Department, Fakeeh College for Medical Sciences
• Jul 2018 – Mar 2019: Associate Professor
  Pharmaceutical Chemistry Department, College of Pharmacy, Al-Azhar University, Cairo, Egypt
• Apr 2015 – Jul 2018: Associate Professor
  Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Almadinah Almunawarah, KSA
• Sep 2010 – Apr 2015: Assistant Professor
  Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Almadinah Almunawarah, KSA
• Dec 2009 - Sep 2010: Assistant Professor
  Pharmaceutical Chemistry Department, Faculty of Pharmacy, Pharmaceutical Chemistry department, Al-Azhar University, Cairo, Egypt
• Dec 2006 - Dec 2009: PhD. Graduate Student
  Pharmaceutical Chemistry Department, University of New York at Buffalo, New York, USA
• Mar 2006 - Dec 2009: Lecturer
  Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alazhar University
• Sept 2000 - Mar 2006: Demonstrator
  Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University
  York at Buffalo, New York, USA

Publications

1. Abulkhair SH., Elmeligie S., Ghiaty A., El‐Morsy A., Bayoumi HA., El‐Adl K., Zayed MF., Hassan HM., Akl EN., El‐Zoghbi SM., Ahmed EA. In vivo‐ and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors. Archiv der Pharmazie. (2021); 354,5, 2000449
2. El-Zahabi AM., Sakr H., El-Adl K., Zayed MF., Abdelraheem SA., Eissa IS., Elkady H., Eissa HI. Design, synthrsis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents. Bioorg. Chem. (2020), 104, 104218.
3. El-Helby AA., Ayyad AR., Zayed MF., Abulkhir SH., Elkady H., El-Adl K. Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants. Archiv der Pharmazie. (2019) Mar 17, (2019); 352 (5), 1800373
4. Zayed MF., Ibrahim S., Habib EE, Hassan MH, Ahmed S, Rateb HS. Design, synthesis, antimicrobial and anti-biofilm evaluation, and molecular docking of new substituted fluoroquinazolinones. Medicinal Chemistry. (2019);15(6):659-675.
5. Zayed MF., Rateb H., Ahmed S., , Khaled O., Ibrahim S. Quinazolinone-amino acid hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization. Molecules (2018); 23, 1699, 1731, 1-17.
6. Ihmaid S., Ahmed H.E., Zayed MF. The Design and Development of Potent Small Molecules as Anticancer Agents Targeting EGFR TK and Tubulin Polymerization. International journal of molecular sciences (2018); 19,408, 1-14.
7. Ibrahim S, Mohamed G, Al Haidari, Amal A. Zayed MF., Khayat M. Tagetnoic acid, a new lipoxygenase inhibitor peroxy fatty acid from Tagetes minuta growing in Saudi Arabia. Natural Product Research. (2018), 34,4,1.
8. Ibrahim S, Mohamed G, Khayat M, Zayed MF, El-Kholy A. Anti-inflammatory terpenoids from Cyperus rotundus rhizomes. Pakistan journal of pharmaceutical sciences (2018); 31(3), 1449-1456
9. Zayed MF., Ahmed S., Ihmaid S., Ahmed HE., Rateb H., Ibrahim S. Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects. International journal of molecular sciences (2018); 19, 1731, 1-16.
10. Ibrahim S, Mohamed G, Al Haidari R, El-Kholy A, Asfour H, Zayed MF. Fusaristerol A: A new cytotoxic and antifungal ergosterol fatty acid ester from the endophytic fungus Fusarium sp. associated with Mentha longifolia roots. Phrmacognosy Magazine (2018), 14(56), 308-311
11. Ibrahim S., Mohamed G., Al Haidari R., El-Kholy A., Zayed MF. Potential Anti-Malarial Agents from Endophytic Fungi: A Review. Mini Review Medicinal Chemistry (2018) 18(13), 1110-1132.
12. Ibrahim S., Mohamed G., Haidari R., El-Kholy A., Zayed MF., Ingenine F: A New Cytotoxic Tetrahydro Carboline Alkaloid from the Indonesian Marine Sponge Acanthostrongylophora ingens. Pharmacognosy Magazine (2018); 14(54):231-234.
13. Ibrahim S., Khedr A., Mohamed G., Zayed MF., El-Kholy A., Al Haidari R. Cucumol B, a new triterpene benzoate from Cucumis melo seeds with cytotoxic effect toward ovarian and human breast adenocarcinoma. Journal of Asian Natural Produts research (2018); 27, 1-7.
14. Ibrahim S., Abdalla H., El-Halawany A., Radwane M., Shehata I., Al-Harshany E., Zayed MF., Mohamed G. Garcixanthones B and C, new xanthones from the pericarps of Garciniamangostana and their cytotoxic activity. Phytochemistry Letters (2018); 25, 12-16.
15. Ibrahim S., Mohamed G., Al Haidari R., El-Kholy A., Mohamed Zayed MF., Khayath M. Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities. Fitoterapia (2018); 129, 317-365.
16. Ibrahima S., Mohamed G, Alshalie K., Al Haidaria r., Kholy A., Zayed MF. Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts. Brazilian journal of Pharmacognosy (2018); 28, 320-324.
17. Ibrahim SM., Mohamed GA., Rwaida A. Al Haidari RA., Zayed MF., Elkhayat ES., Ross SA., Fusarithioamide B, a new benzamide derivative from the endophytic fungus Fusarium chlamydosporium with potent cytotoxic and antimicrobial activities. Bioorganic & Medicinal Chemistry (2018) 26, 786-790.
18. Ahmed HE., Ihmaid SK., Omar AM., Shehata AM., Rateb HS., Zayed MF., Ahmed S., Elaasser MM. Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents. Bioorganic Chemistry. (2018); 76, 332-342.
19. Ibrahim SM., Mohamed GA., Al haidari RA., Zayed MF., Elfaky MA. Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana. Journal of Asian Natural Produts research (2018); 1-7.
20. Sabrin MI., Gamal AM., Zayed MF. Genus Hylocereus: Beneficial phytochemicals, nutritional importance, and biological relevance. Journal of food biochemistry (2018); 1-29.
21. Ibrahim SM., Abdallah HM., El-khayat ES., Mohamed GA., Zayed MF., Fusaripeptide A: new antifungal and anti-malarial cyclodepsipeptide from the endophytic fungus Fusarium sp. Journal of Asian Natural Products Research (2018);20(1)-75-85.
22. Sabrin MI., Gamal AM., Zayed MF. Mangostanaxanthone VII, a new cytotoxicxanthone from Garcinia mangostana. Z. Naturforsch (2017); 1-5.
23. Zayed M.F., Ahmed HEA., Ihmaid Synthesis, El-Adl K., Asiri A., Omar MA. Modelling and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor. Molecules (2017); 22, 1-15.
24. Ihmaid S., Ahmed H.E., Ali AA., Sherif YE., Tarazi HM., Riyadh SM., Zayed MF., Abulkhair HS., Rateb HA. Rational Design, Synthesis, Pharmacophore Modeling, and Docking Studies for Identification of Novel Potent DNA-PK Inhibitors. Bioorganic Chemistry. (2017); 72, 234-247.
25. Ibrahim SM., Abdallah HM., El-khayat ES., Mohamed GA., Zayed MF., Fusaripeptide A: new antifungal and anti-malarial cyclodepsipeptide from the endophytic fungus Fusarium sp. Journal of Asian Natural Products Research (2017);1-11.
26. Ibrahim SM., Mohamed GA., Zayed M.F., Samir A. Ross. Hydroxyirilone 5-methyl ether and 8-hydroxyirilone, new antioxidant and a-amylase inhibitors isoflavonoids from Iris germanica rhizomes. Bioorganic Chemistry (2017); 70, 192-198.
27. Ahmed S., Zayed MF., El-Messery MS., El-Agmy MA., Abdel-Rahman HM. Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of 1,2,4-Triazole-Based4-Thiazolidinones. Molecules (2016); 21, 1-17.
28. Ihmaid SK., Ahmed HEA., Zayed MF., Abadleh MM. Self-Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits. Molecules (2016); 1-16.
29. Zayed MF., Ahmed HEA., Ihmaid SK., Omar AM, Abdelrahim AS. Synthesis and screening of some new fluorinated quinazolinone–sulphonamide hybrids as anticancer agents. Journal of Taibah University Medical Sciences (2015); 10(3): 333–339.
30. Ibrahim SM., Mohamed GA., Zayed MF., Hanaa MS. Ingenines A and B, Two New Alkaloids from the Indonesian Sponge Acanthostrongylophora. Drug Research (2015); 65, 361-365.
31. Ahmed HEA., Zayed MF., Ihmaid SK. Molecular pharmacophore selectivity studies, virtual screening, and in silico ADMET analysis of GPCR antagonists. Medicinal Chemistry Research (2015); 24(9): 3537-3550.
32. Ibrahim MK., El-Adl K., Zayed MF., Mahdy HA. Design, synthesis, docking, and biological evaluation of some novel 5-chloro-2-substituted sulfanylbenzoxazole derivatives as anticonvulsant agents. Medicinal Chemistry Research (2014); 24(1): 99-114.
33. Zayed MF. New fluorinated quinazolinone derivatives as anticonvulsant agents Journal of Taibah University Medical Sciences (2014); 9:104-109.
34. Zayed MF., Hassan MH. Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents. Saudi Pharmaceutical Journal (2014); 22: 157-162.
35. Zayed MF., Hassan MH. Design, Synthesis and Biological Evaluation Studies of Novel Quinazoline Derivatives as Cytotoxic Agents. Drug Research (2013); 63:210-215.
36. Zayed MF., Ahmed EA, Omar AM, Abdelrahim AS Khaled El-Adl. Design, synthesis, and biological evaluation studies of novel quinazolinone derivatives as anticonvulsant agents. Medicinal Chemistry Research (2013); 22(12):5823-5831.
37. Zayed MF., Ayyad RR. Some novel anticonvulsant agents derived from Phthalazinedione. Arzneimittelforschung (2012); 62: 532–536.
38. Elhelby AA, Ayyad RR, Zayed MF. Synthesis and biological evaluation of some quinoxaline derivatives as anticonvulsant agents. Arzneimittelforschung (2011); 61(7):379-381.
39. Englert L, Biela A, Zayed MF., Heine A, Hangauer D, Klebe G. Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: Binding of phosphonamidate to the S1'-pocket of thermolysin. Biochimica et Biophysica Acta. (2010); 1800:1192-1202.
40. Baum B, Mohamed M, Zayed MF., Gerlach C, Heine A, Hangauer D, Klebe G «More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Non basic Residues in the S1 Pocket of Thrombin». Journal of Molecular Biology. (2009); 390(1):56-69.
41. Bayomi, AH, El-Helby AA, Abdel Rahman AA, Zayed MF. Synthesis and anticonvulsant activity of some new 2-styryl-4(3H)quinazolinone derivatives. Egypt Journal of Biomedical Science (2005); 19:216-225.
42. M Freindorf, J Kong, B Baum, M Mohamed, M Zayed, G Klebe. QM/MM study of the interaction between thrombin and its protein inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2010), 239, 1155 16TH ST, NW
43. DG Hangauer, G Klebe, M Freindorf, M Smolinski, L Muley, M Mohamed. Unraveling the fundamental forces controlling drug-receptor binding affinity with in-depth combined experimental-theoretical approach. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2009), 238, 1155 16TH ST, NW
44. M Freindorf, J Kong, B Baum, M Mohamed, M Zayed, G Klebe. Large-scale QM/MM calculations of protein-ligand interaction in Thrombin S1 pocket ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2009), 238, 1155 16TH ST, NW

Email

mfzayed.fcms.edu.sa

mfzayed@fakeeh.care